Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC072
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-23 12:05
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment OLD PATIENT OPRYMEA 1X1 PK MERZ 2+1+0 madopar 3x1\4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 34 individuals with a value less than 0.65 were subsequently diagnosed with PD. That is, 80.95% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.65 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 19, 'TN': 14, 'TP': 23, 'FP': 16}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 32, 'TN': 26, 'TP': 10, 'FP': 4}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 39, 'TN': 29, 'TP': 3, 'FP': 1}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 11, 'TP': 22, 'FP': 19}

Test Battery Details

Circle

numCircles 11
timePerCircleMean 17.0036
timePerCircleCoV 0.244774
timePerCircleSlope -0.0643071
meanError 1.69282
tremorFreq 5.95703
tremorRelPower 22.5127
tremorGyroAmpMean 0.0146722
tremorGyroAmpSlope -0.000184098
tremorGyroAmpCoV 0.374795
tremorCoordAmpMean 0.0289568
tremorCoordAmpSlope 0.0018463
tremorCoordAmpCoV 0.287262
tremorAccAmpMean 0.0239648
tremorAccAmpSlope 0.00117957
tremorAccAmpCoV 0.384091
tremorPcRelVar 0.523609
tremorPcX -0.208023
tremorPcY 0.978124

Circle Segment 1

Duration 27.04 s, Accuracy Estimate 1.842 (lower is better)

Circle Segment 2

Duration 21.68 s, Accuracy Estimate 2.129 (lower is better)

Circle Segment 3

Duration 18.08 s, Accuracy Estimate 1.446 (lower is better)

Circle Segment 4

Duration 17.52 s, Accuracy Estimate 1.718 (lower is better)

Circle Segment 5

Duration 16.76 s, Accuracy Estimate 1.59 (lower is better)

Circle Segment 6

Duration 14.72 s, Accuracy Estimate 1.743 (lower is better)

Circle Segment 7

Duration 16.24 s, Accuracy Estimate 1.709 (lower is better)

Circle Segment 8

Duration 14.08 s, Accuracy Estimate 1.482 (lower is better)

Circle Segment 9

Duration 13.48 s, Accuracy Estimate 1.289 (lower is better)

Circle Segment 10

Duration 14.36 s, Accuracy Estimate 1.36 (lower is better)

Circle Segment 11

Duration 13.08 s, Accuracy Estimate 2.312 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 44.8333
timePerSpiralCoV 0.0777641
timePerSpiralSlope -0.0256697
meanError 2.12786
tremorFreq 7.32422
tremorRelPower 32.3282
tremorGyroAmpMean 0.0274704
tremorGyroAmpSlope 0.00216981
tremorGyroAmpCoV 0.534718
tremorCoordAmpMean 0.0412708
tremorCoordAmpSlope 0.000977976
tremorCoordAmpCoV 0.40356
tremorAccAmpMean 0.0403287
tremorAccAmpSlope 0.00137172
tremorAccAmpCoV 0.451356
tremorPcRelVar 0.602941
tremorPcX -0.990182
tremorPcY 0.139783

Spiral Segment 1

Duration 50.88 s, Accuracy Estimate 1.865 (lower is better)

Spiral Segment 2

Duration 42.72 s, Accuracy Estimate 2.285 (lower is better)

Spiral Segment 3

Duration 46.88 s, Accuracy Estimate 1.903 (lower is better)

Spiral Segment 4

Duration 42.52 s, Accuracy Estimate 2.864 (lower is better)

Spiral Segment 5

Duration 41.68 s, Accuracy Estimate 2.008 (lower is better)

Spiral Segment 6

Duration 44.32 s, Accuracy Estimate 1.841 (lower is better)

Elel

eDurationMean 1.30631
eDurationStd 0.301507
eDurationStdnorm 0.230808
eDurationMedian 1.2575
eDurationQuartdelta 0.245
eDurationQuartdeltanorm 0.194831
eDurationKurt 9.14978
eDurationTrenddiff -0.11
eDurationTrendratio 0.919118
eWidthMean 4.94743
eWidthStd 1.28876
eWidthStdnorm 0.260491
eWidthMedian 4.914
eWidthQuartdelta 1.872
eWidthQuartdeltanorm 0.380952
eWidthKurt 2.48439
eWidthTrenddiff -1.638
eWidthTrendratio 0.702128
eHeightMean 9.68871
eHeightStd 1.44853
eHeightStdnorm 0.149507
eHeightMedian 9.4185
eHeightQuartdelta 1.287
eHeightQuartdeltanorm 0.136646
eHeightKurt 3.3953
eHeightTrenddiff 0.468
eHeightTrendratio 1.05063
eAspectMean 0.518753
eAspectStd 0.144271
eAspectStdnorm 0.278112
eAspectMedian 0.511806
eAspectQuartdelta 0.258784
eAspectQuartdeltanorm 0.50563
eAspectKurt 1.98801
eAspectTrenddiff -0.168157
eAspectTrendratio 0.701436
eSlantMean -0.0593329
eSlantStd 0.15565
eSlantStdnorm -2.62333
eSlantMedian -0.0592105
eSlantQuartdelta 0.216099
eSlantQuartdeltanorm -3.64967
eSlantKurt 3.41422
eSlantTrenddiff -0.0278148
eRtopMean 0.675896
eRtopStd 0.112689
eRtopStdnorm 0.166725
eRtopMedian 0.685243
eRtopQuartdelta 0.135076
eRtopQuartdeltanorm 0.197122
eRtopKurt 2.33033
eRtopTrenddiff -0.0654762
eRbotMean 0.838825
eRbotStd 0.301384
eRbotStdnorm 0.359293
eRbotMedian 0.808711
eRbotQuartdelta 0.36771
eRbotQuartdeltanorm 0.454686
eRbotKurt 3.892
eRbotTrenddiff -0.0524109
eRrightMean 0.797733
eRrightStd 0.0610671
eRrightStdnorm 0.0765508
eRrightMedian 0.804972
eRrightQuartdelta 0.0602854
eRrightQuartdeltanorm 0.0748913
eRrightKurt 2.76606
eRrightTrenddiff -0.0230011
eRleftMean 0.465993
eRleftStd 0.144123
eRleftStdnorm 0.30928
eRleftMedian 0.452079
eRleftQuartdelta 0.206692
eRleftQuartdeltanorm 0.457203
eRleftKurt 2.25561
eRleftTrenddiff 0.0256046
lDurationMean 1.68716
lDurationStd 0.264156
lDurationStdnorm 0.156568
lDurationMedian 1.67
lDurationQuartdelta 0.285
lDurationQuartdeltanorm 0.170659
lDurationKurt 2.88517
lDurationTrenddiff -0.2375
lDurationTrendratio 0.869505
lWidthMean 5.1733
lWidthStd 0.836518
lWidthStdnorm 0.161699
lWidthMedian 5.148
lWidthQuartdelta 1.2285
lWidthQuartdeltanorm 0.238636
lWidthKurt 2.66291
lWidthTrenddiff -0.0585
lWidthTrendratio 0.988636
lHeightMean 16.4338
lHeightStd 2.76028
lHeightStdnorm 0.167964
lHeightMedian 15.678
lHeightQuartdelta 3.042
lHeightQuartdeltanorm 0.19403
lHeightKurt 3.768
lHeightTrenddiff -1.638
lHeightTrendratio 0.903114
lAspectMean 0.320605
lAspectStd 0.063998
lAspectStdnorm 0.199617
lAspectMedian 0.320988
lAspectQuartdelta 0.0876513
lAspectQuartdeltanorm 0.273068
lAspectKurt 3.95442
lAspectTrenddiff 0.0440749
lAspectTrendratio 1.15172
lSlantMean -0.127422
lSlantStd 0.0976458
lSlantStdnorm -0.766317
lSlantMedian -0.134328
lSlantQuartdelta 0.147325
lSlantQuartdeltanorm -1.09675
lSlantKurt 2.69998
lSlantTrenddiff 0.0539491
lRtopMean 0.6099
lRtopStd 0.159436
lRtopStdnorm 0.261413
lRtopMedian 0.657895
lRtopQuartdelta 0.224747
lRtopQuartdeltanorm 0.341616
lRtopKurt 2.30144
lRtopTrenddiff 0.0906181
lRbotMean 1.03072
lRbotStd 0.324701
lRbotStdnorm 0.315023
lRbotMedian 0.928571
lRbotQuartdelta 0.4246
lRbotQuartdeltanorm 0.457261
lRbotKurt 4.01643
lRbotTrenddiff -0.0416234
lRrightMean 0.74278
lRrightStd 0.104596
lRrightStdnorm 0.140817
lRrightMedian 0.774775
lRrightQuartdelta 0.156994
lRrightQuartdeltanorm 0.202632
lRrightKurt 2.27464
lRrightTrenddiff -0.0431548
lRleftMean 0.495135
lRleftStd 0.159455
lRleftStdnorm 0.322044
lRleftMedian 0.503817
lRleftQuartdelta 0.220239
lRleftQuartdeltanorm 0.437141
lRleftKurt 2.41721
lRleftTrenddiff -0.117334

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.939405
sumTouchScores 18.7881
meanMovementTime 0.960526
numTouches 20
undershootPercentage 0
overshootPercentage 5

FITTS Long Modified

meanTouchScore 0.987438
sumTouchScores 15.799
meanMovementTime 1.14467
numTouches 16
undershootPercentage 0
overshootPercentage 6.25

ZigZag

numZigzags 5
timePerZigzagMean 55.392
timePerZigzagCoV 0.0498094
timePerZigzagSlope 0.0267909
meanError 1.36542
tremorFreq 6.44531
tremorRelPower 26.1481
tremorGyroAmpMean 0.0244093
tremorGyroAmpSlope 0.000671287
tremorGyroAmpCoV 0.498024
tremorCoordAmpMean 0.0370844
tremorCoordAmpSlope -5.57807e-05
tremorCoordAmpCoV 0.393255
tremorAccAmpMean 0.0348296
tremorAccAmpSlope -3.36777e-05
tremorAccAmpCoV 0.35093
tremorPcRelVar 0.60469
tremorPcX 0.0960177
tremorPcY -0.99538

ZigZag Segment 1

Duration 53.44 s, Accuracy Estimate 1.626 (lower is better)

ZigZag Segment 2

Duration 53.68 s, Accuracy Estimate 1.239 (lower is better)

ZigZag Segment 3

Duration 53.04 s, Accuracy Estimate 1.225 (lower is better)

ZigZag Segment 4

Duration 58.2 s, Accuracy Estimate 1.325 (lower is better)

ZigZag Segment 5

Duration 58.6 s, Accuracy Estimate 1.411 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 37.232
timePerZigzagCoV 0.126256
timePerZigzagSlope -0.0278255
zigzagHeightMean 45.9146
zigzagHeightCoV 0.113225
zigzagHeightSlope 0.0696473
meanError 0.0675368
tremorFreq 6.54297
tremorRelPower 25.8512
tremorGyroAmpMean 0.0214302
tremorGyroAmpSlope 0.00254851
tremorGyroAmpCoV 0.379346
tremorCoordAmpMean 0.034781
tremorCoordAmpSlope 0.00309897
tremorCoordAmpCoV 0.336602
tremorAccAmpMean 0.0299798
tremorAccAmpSlope 0.00357239
tremorAccAmpCoV 0.358409
tremorPcRelVar 0.590464
tremorPcX 0.028508
tremorPcY -0.999594

ZigZag Offset Segment 1

Duration 34.4 s, Accuracy Estimate 0.095 (lower is better)

ZigZag Offset Segment 2

Duration 40.88 s, Accuracy Estimate 0.086 (lower is better)

ZigZag Offset Segment 3

Duration 42.8 s, Accuracy Estimate 0.051 (lower is better)

ZigZag Offset Segment 4

Duration 36.84 s, Accuracy Estimate 0.043 (lower is better)

ZigZag Offset Segment 5

Duration 31.24 s, Accuracy Estimate 0.062 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.86}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.65}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.5739152334770619}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9433142880132215}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.847788404401072}